9/10/2023 0 Comments 23-06-23 989 for mac downloadMaxof 6.72 mcg/mL (range: 4.12 to 8.08 mcg/mL) and after single oral doses of 50 to 400 mg, fluconazole plasma concentrations and area under the plasma concentration-time curve (AUC) are dose proportional. In fasted normal volunteers, administration of a single oral 400 mg dose of fluconazole leads to a mean C Max) in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. Bioequivalence was established between the 100 mg tablet and both suspension strengths when administered as a single 200 mg dose. In normal volunteers, the bioavailability of orally administered fluconazole is over 90% compared with intravenous administration. The pharmacokinetic properties of fluconazole are similar following administration by the intravenous or oral routes.
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